Fructose
restricts blood flow to the brain’s cerebral cortex, which is involved in self-control, as well as the hippocampus and thalamus. Simultaneously, blood flow increases around the visual cortex, a region associated with food reward. All of this together helps stimulate the foraging response.
“We believe that initially the fructose-dependent reduction in cerebral metabolism in these regions was reversible and meant to be beneficial,” Prof. Johnson adds. “But chronic and persistent reduction in cerebral metabolism driven by recurrent fructose metabolism leads to progressive brain atrophy and neuron loss with all of the features of AD.”
Prof. Johnson theorizes that this survival response, which he calls a “survival switch,” helped ancient humans survive periods of extreme scarcity. Today, however, that survival switch is still on, so to speak, in a time of relative abundance. This promotes the overeating of high fat, sugary and salty foods resulting in excess fructose production.
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